A tale of unfortunate circumstances, Pandora's Tower from XSEED Games for the Nintendo Wii opens in the Kingdom of Elyria, where an unassuming singer named Elena succumbs to a wretched curse during a festival performance.

Bearing an arcane mark on her back, she starts transforming into a savage monster, causing the town guards to attempt to kill her in order to prevent it.

A young ex-mercenary named Aeron, whose heart has forever been pledged to Elena, whisks her away in the nick of time - and with the help of a mysterious witch named Mavda, he learns what must be done to avert her wretched fate.

He must descend into The Scar, a massive chasm tied down by twelve chains connected to a floating island in its center, atop which sit thirteen interconnected towers. There, he must use his sword and a sacred chain to battle his way through each tower and extract the flesh of the boss "masters" that dwell within, which Elena must consume in order to reverse her ongoing transformation. But the clock is ticking!

The longer Aeron takes to vanquish each beast, the less human Elena becomes, affecting her character and the game's final outcome in a profound manner. Time is of the essence...